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Articles (41)
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Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs

Forman, Mark S, Trojanowski, John Q, Lee, Virginia M-Y

Journal:

Nature Medicine

Année:

2004

Langue:

english

Fichier:

PDF, 1.25 MB

english, 2004

Antibody labeling of bovine neurofilaments: implications on the structure of neurofilament sidearms

Lizanne Mulligan, Brian J. Balinj, Virginia M-Y. Lee, Wallace Ip

Journal:

Journal of Structural Biology

Année:

1991

Langue:

english

Fichier:

PDF, 17.59 MB

english, 1991

N EURODEGENERATIVE T AUOPATHIES

Lee, Virginia M-Y, Goedert, Michel, Trojanowski, John Q

Journal:

Annual Review of Neuroscience

Année:

2001

Langue:

english

Fichier:

PDF, 502 KB

english, 2001

Unexpected abundance of pathological tau in progressive supranuclear palsy white matter

Victoria Zhukareva, Sonali Joyce, Teresa Schuck, Vivianna Van Deerlin, Howard Hurtig, Roger Albin, Sid Gilman, Steven Chin, Bruce Miller, John Q. Trojanowski, Virginia M-Y. Lee

Journal:

Annals of Neurology

Année:

2006

Langue:

english

Fichier:

PDF, 1.50 MB

english, 2006

The cytoskeleton in neurodegenerative diseases

Nigel J Cairns, Virginia M-Y Lee, John Q Trojanowski

Journal:

The Journal of Pathology

Année:

2004

Langue:

english

Fichier:

PDF, 464 KB

english, 2004

Frontotemporal dementia and tauopathy

Yasumasa Yoshiyama, Virginia M-Y Lee, John Q. Trojanowski

Journal:

Current Neurology and Neuroscience Reports

Année:

2001

Langue:

english

Fichier:

PDF, 369 KB

english, 2001

Vitamin E reduces amyloidosis and improves cognitive function in Tg2576 mice following repetitive concussive brain injury

Valeria Conte, Kunihiro Uryu, Scott Fujimoto, Yuemang Yao, Joshua Rokach, Luca Longhi, John Q. Trojanowski, Virginia M-Y. Lee, Tracy K. McIntosh, Domenico Praticò

Journal:

Journal of Neurochemistry

Année:

2004

Langue:

english

Fichier:

PDF, 47 KB

english, 2004

Is the Initial Insult in Parkinson's Disease and Dementia with Lewy Bodies a Neuritic Dystrophy?

JOHN E. DUDA, BENOIT I. GIASSON, VIRGINIA M-Y. LEE, JOHN Q. TROJANOWSKI

Journal:

Annals of the New York Academy of Sciences

Année:

2003

Fichier:

PDF, 425 KB

2003

Parkinson's Disease and Related α-Synucleinopathies Are Brain Amyloidoses

JOHN Q. TROJANOWSKI, VIRGINIA M-Y. LEE

Journal:

Annals of the New York Academy of Sciences

Année:

2003

Fichier:

PDF, 132 KB

2003

Pathological tau: a loss of normal function or a gain in toxicity?

Trojanowski, John Q, Lee, Virginia M-Y

Journal:

Nature Neuroscience

Année:

2005

Langue:

english

Fichier:

PDF, 248 KB

english, 2005

Fatal attractions: abnormal protein aggregation and neuron death in Parkinson's disease and Lewy body dementia

Trojanowski, John Q, Goedert, Michel, Iwatsubo, Takeshi, Lee, Virginia M-Y

Journal:

Cell Death & Differentiation

Année:

1998

Langue:

english

Fichier:

PDF, 147 KB

english, 1998

Vitamin E reduces amyloidosis and improves cognitive function in Tg2576 mice following repetitive concussive brain injury

Valeria Conte, Kunihiro Uryu, Scott Fujimoto, Yuemang Yao, Joshua Rokach, Luca Longhi, John Q. Trojanowski, Virginia M-Y. Lee, Tracy K. McIntosh, Domenico Praticò

Journal:

Journal of Neurochemistry

Année:

2004

Langue:

english

Fichier:

PDF, 149 KB

english, 2004

TDP-43: a novel neurodegenerative proteinopathy

Mark S Forman, John Q Trojanowski, Virginia M-Y Lee

Journal:

Current Opinion in Neurobiology

Année:

2007

Langue:

english

Fichier:

PDF, 557 KB

english, 2007

Disruption of the cytoskeleton in Alzheimer's disease

Virginia M-Y Lee

Journal:

Current Opinion in Neurobiology

Année:

1995

Langue:

english

Fichier:

PDF, 481 KB

english, 1995

Nosology of Parkinson’s Disease: Looking for the Way Out of a Quackmire

Mark S. Forman, Virginia M-Y. Lee, John Q. Trojanowski

Journal:

Neuron

Année:

2005

Langue:

english

Fichier:

PDF, 119 KB

english, 2005

More than just two peas in a pod: common amyloidogenic properties of tau and α-synuclein in neurodegenerative diseases

Virginia M-Y Lee, Benoit I Giasson, John Q Trojanowski

Journal:

Trends in Neurosciences

Année:

2004

Langue:

english

Fichier:

PDF, 557 KB

english, 2004

Brain Trauma Induces Massive Hippocampal Neuron Death Linked to a Surge in β-Amyloid Levels in Mice Overexpressing Mutant Amyloid Precursor Protein

Douglas H. Smith, Michio Nakamura, Tracy K. McIntosh, Jun Wang, Amarís Rodríguez, Xiao-Han Chen, Ramesh Raghupathi, Kathryn E. Saatman, James Clemens, M. Luise Schmidt, Virginia M-Y Lee, John Q. Troja

Journal:

The American Journal of Pathology

Année:

1998

Langue:

english

Fichier:

PDF, 1.00 MB

english, 1998

β-Secretase revealed: starting gate for race to novel therapies for Alzheimer’s disease

Daniel M Skovronsky, Virginia M-Y Lee

Journal:

Trends in Pharmacological Sciences

Année:

2000

Langue:

english

Fichier:

PDF, 81 KB

english, 2000

‘Unfolding’ pathways in neurodegenerative disease

Mark S Forman, Virginia M-Y Lee, John Q Trojanowski

Journal:

Trends in Neurosciences

Année:

2003

Langue:

english

Fichier:

PDF, 268 KB

english, 2003

Increased isoprostane biosynthesis in alzheimer's disease: Correlation of a specific non invasive index of lipid peroxidation with disease severity

Domenico Pratico, Christopher C. Clark, Virginia M-Y. Lee, John Q. Trojanowski, Garret A. FitzGerald

Journal:

Neurobiology of Aging

Année:

2000

Langue:

english

Fichier:

PDF, 179 KB

english, 2000

Reversible β-pleated sheet formation of a phosphorylated synthetic τ peptide

Emma Lang, Gyorgyi I. Szendrei, Ilona Elekes, Virginia M-Y. Lee, Laszlo Otvos Jr.

Journal:

Biochemical and Biophysical Research Communications

Année:

1992

Langue:

english

Fichier:

PDF, 416 KB

english, 1992

Monoclonal and polyclonal antibodies against neural antigens: Diagnostic applications for studies of central and peripheral nervous system tumors

John Q. Trojanowski, Virginia M-Y Lee

Journal:

Human Pathology

Année:

1983

Langue:

english

Fichier:

PDF, 1.15 MB

english, 1983

Microtubule-stabilising drugs for therapy of Alzheimer’s disease and other neurodegenerative disorders with axonal transport impairments

Trojanowski, John Q, Smith, Amos B, Huryn, Donna, Lee, Virginia M-Y

Journal:

Expert Opinion on Pharmacotherapy

Année:

2005

Langue:

english

Fichier:

PDF, 66 KB

english, 2005

Clinical and Biochemical Differences in Patients Having Parkinson Disease With vs Without GBA Mutations

Chahine, Lama M., Qiang, Judy, Ashbridge, Emily, Minger, James, Yearout, Dora, Horn, Stacy, Colcher, Amy, Hurtig, Howard I., Lee, Virginia M-Y., Van Deerlin, Vivianna M., Leverenz, James B., Siderowf,

Journal:

JAMA Neurology

Année:

2013

Langue:

english

Fichier:

PDF, 365 KB

english, 2013

Transmission of alpha-synuclein in Parkinson’s disease

Virginia M-Y Lee

Journal:

Molecular Neurodegeneration

Année:

2013

Langue:

english

Fichier:

PDF, 73 KB

english, 2013

Therapeutic modulation of eIF2α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models

Kim, Hyung-Jun, Raphael, Alya R, LaDow, Eva S, McGurk, Leeanne, Weber, Ross A, Trojanowski, John Q, Lee, Virginia M-Y, Finkbeiner, Steven, Gitler, Aaron D, Bonini, Nancy M

Journal:

Nature Genetics

Année:

2013

Langue:

english

Fichier:

PDF, 1.51 MB

english, 2013

Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite–like aggregates

Volpicelli-Daley, Laura A, Luk, Kelvin C, Lee, Virginia M-Y

Journal:

Nature Protocols

Année:

2014

Langue:

english

Fichier:

PDF, 925 KB

english, 2014

Toxicity and Neuronal Infection of a HSV-1 ICP34.5 Mutant in Nude Mice

Lasner, Todd M, Tal-Singer, Ruth, Kesari, Santosh, Lee, Virginia M-Y, Trojanowski, John Q, Fraser, Nigel W

Journal:

Journal of NeuroVirology

Année:

1998

Langue:

english

Fichier:

PDF, 730 KB

english, 1998

Aminothienopyridazines as imaging probes of tau pathology: a patent evaluation of WO2013090497

Ballatore, Carlo, Smith, Amos B, Lee, Virginia M-Y, Trojanowski, John Q, Brunden, Kurt R

Journal:

Expert Opinion on Therapeutic Patents

Année:

2014

Langue:

english

Fichier:

PDF, 694 KB

english, 2014

Differential induction and spread of tau pathology in young PS19 tau transgenic mice following intracerebral injections of pathological tau from Alzheimer’s disease or corticobasal degeneration brains

Boluda, Susana, Iba, Michiyo, Zhang, Bin, Raible, Kevin M., Lee, Virginia M-Y., Trojanowski, John Q.

Journal:

Acta Neuropathologica

Année:

2015

Langue:

english

Fichier:

PDF, 13.06 MB

english, 2015

Intracellular APP Processing and Aβ Production in Alzheimer Disease

Wilson, Christina A., Doms, Robert W., Lee, Virginia M-Y

Journal:

Journal of Neuropathology and Experimental Neurology

Année:

1999

Fichier:

PDF, 477 KB

1999

Accumulation of Intracellular Amyloid-β Peptide (Aβ 1–40) in Mucopolysaccharidosis Brains

Ginsberg, Stephen D., Galvin, James E., Lee, Virginia M-Y, Rorke, Lucy B., Dickson, Dennis W., Wolfe, John H., Jones, Margaret Z., Trojanowski, John Q.

Journal:

Journal of Neuropathology and Experimental Neurology

Année:

1999

Fichier:

PDF, 846 KB

1999

Myosin Va Binding to Neurofilaments Is Essential for Correct Myosin Va Distribution and Transport and Neurofilament Density

Mala V. Rao, Linda J. Engle, Panaiyur S. Mohan, Aidong Yuan, Dike Qiu, Anne Cataldo, Linda Hassinger, Stephen Jacobsen, Virginia M-Y. Lee, Athena Andreadis, Jean-Pierre Julien, Paul C. Bridgman and Ra

Journal:

The Journal of Cell Biology

Année:

2002

Langue:

english

Fichier:

PDF, 3.69 MB

english, 2002

Altered microtubule dynamics in neurodegenerative disease: Therapeutic potential of microtubule-stabilizing drugs

Brunden, Kurt R., Lee, Virginia M-Y., Smith, Amos B., Trojanowski, John Q., Ballatore, Carlo

Journal:

Neurobiology of Disease

Année:

2016

Langue:

english

Fichier:

PDF, 684 KB

english, 2016

PERFORMANCE EVALUATION OF NEW ABSORBANCE-BASED ELISAS FOR MEASURING DIFFERENT ALPHA-SYNUCLEIN (A-SYN) SPECIES IN CSF AND PLASMA

Stoops, Erik, Majbour, Nour, Mauroo, Kimberley, Demeyer, Leentje, Lashuel, Hilal, Trojanowski, John Q., M-Y Lee, Virginia, El Agnaf, Omar, Vanderstichele, Hugo Marcel

Journal:

Alzheimer's & Dementia

Année:

2016

Langue:

english

Fichier:

PDF, 578 KB

english, 2016

Distinct binding of PET ligands PBB3 and AV-1451 to tau fibril strains in neurodegenerative tauopathies

Ono, Maiko, Sahara, Naruhiko, Kumata, Katsushi, Ji, Bin, Ni, Ruiqing, Koga, Shunsuke, Dickson, Dennis W., Trojanowski, John Q., Lee, Virginia M-Y., Yoshida, Mari, Hozumi, Isao, Yoshiyama, Yasumasa, va

Journal:

Brain

Année:

2017

Langue:

english

Fichier:

PDF, 2.11 MB

english, 2017

CELL-TO-CELL TRANSMISSION OF PATHOLOGICAL TAU: A POTENTIAL MECHANISM OF DISEASE PROGRESSION IN ALZHEIMER'S AND OTHER TAUOPATHIES

M-Y Lee, Virginia

Journal:

Alzheimer's & Dementia

Année:

2017

Langue:

english

Fichier:

PDF, 260 KB

english, 2017

EMERGING CONCEPTS IN BASIC SCIENCE: PANEL SESSION

Holmes, Clive, Grothe, Michel J., Carare, Roxana O., Herrup, Karl, M-Y Lee, Virginia, Williams, Julie

Journal:

Alzheimer's & Dementia

Année:

2017

Langue:

english

Fichier:

PDF, 260 KB

english, 2017

Apolipoprotein E Highly Correlates with AÎ²PP- and Tau-Related Markers in Human Cerebrospinal Fluid

Vuletic, Simona, Li, Ge, Peskind, Elaine R., Kennedy, Hal, Marcovina, Santica M., Leverenz, James B., Petrie, Eric C., Lee, Virginia M-Y., Galasko, Douglas, Schellenberg, Gerard D., Albers, John J.

Journal:

Journal of Alzheimer's Disease

Année:

2008

Fichier:

PDF, 85 KB

2008

Limbic-predominant age-related TDP-43 encephalopathy differs from frontotemporal lobar degeneration

Robinson, John L, Porta, SÃlvia, Garrett, Filip G, Zhang, Panpan, Xie, Sharon X, Suh, EunRan, Van Deerlin, Vivianna M, Abner, Erin L, Jicha, Gregory A, Barber, Justin M, Lee, Virginia M-Y, Lee, Edwar

Journal:

Brain

Année:

2020

Fichier:

PDF, 1.36 MB

2020

Mechanisms of slow axonal transport of Î±-synuclein

Roy, Subhojit, Winton, Matthew J., Black, Mark M., Trojanowski, John Q., Lee, Virginia M-Y.

Journal:

Journal of Neuropathology and Experimental Neurology

Année:

2007

Fichier:

PDF, 492 KB

2007